Biologia, Bratislava 55/3: 229-234, 2000.

ISSN 0006-3088 (Biologia). ISSN 1335-6399 (Biologia. Section Cellular and Molecular Biology).


Full Paper

Genotoxic effect of vanillin derivatives.


Maria Mikulasova* & Ingrid Bohovicova

Faculty of Chemical Technology, Slovak University of Technology, Radlinskeho 9, SK-81237 Bratislava, Slovakia; tel.: ++421 7 5325528, e-mail:

* corresponding author

Received: August 4, 1999 / Accepted: February 16, 2000



A liquid micromodification of the DNA-repair test with the wild repair-proficient and three repair-deficient strains of Escherichia coli was used for determination of the genotoxic effect of vanillin and its four derivatives. The negative results obtained were confirmed by the assessment of the number of revertants via the Ames test. The ability of vanillin and o-vanillin to increase the viability of cells and to decrease the number of mutations in bacteria pre-treated with 4-nitrochinolin-1-oxide was verified.


Key words: vanillin, genotoxicity, mutagenicity, DNA-repair test.