Biologia, Bratislava, 56/Suppl. 9: 61-64, 2001.

ISSN 0006-3088 (Biologia). ISSN 1335-6399 (Biologia. Section Cellular and Molecular Biology).


Full Paper

Susceptibility of Candida albicans isolated in oral pre-cancerous lesions to selected antifungal agents.


Jana Durovicova1, Leonard Siegfried1*, Marian Sabol1 & Eugen Durovic2

1 Institute of Medical Microbiology, Faculty of Medicine, P. J. Safarik University, Kosice, Srobarova 2, SK-04180 Kosice, Slovakia; tel.: ++ 421 95 6225471, fax: ++ 421 95 642025, e-mail:

2 Clinic of Stomatology and Maxillofacial Surgery, L. Pasteur University Hospital, Rastislavova 43, SK-04000 Kosice, Slovakia

* corresponding author

Received: February 14, 2001 / Accepted: May 29, 2001



Candida is a common yeast, normally occurring in the oral cavity. It becomes a clinical problem when organism transforms from a comensal to a pathogenic state. Predisposing factors which potentiate the transformation of Candida include systemic and local factors. Clinically very important local factors are the oral mucosal lesions, as leukoplakia and lichen planus. These have been classified as oral pre-cancerous lesions. The goal of this study was to get information about incidence of Candida species in oral pre-cancerous lesions and to detect susceptibility of Candida species to antifungal agents. The results of this study demonstrated that the most prevalent Candida species associated with leukoplakia and lichen planus was Candida albicans (C. albicans). Minimum inhibitory concentrations (MICs) ranges of antifungal drugs used in the study for 32 C. albicans were as follows: clotrimazole from 0.03 to 8 g/mL, fluconazole from 0.03 to 64 g/mL, amphotericin B from 0.06 to 64 g/mL, and ketoconazole from 0.03 to 0.5 g/mL. By using the MIC agar dilution test one Candida isolate showed resistance to amphotericin B, clotrimazole and fluconazole.


Key words: Candida albicans, leukoplakia, lichen planus, antifungal agents.