Biologia, Bratislava, 56/Suppl. 9: 87-90, 2001.

ISSN 0006-3088 (Biologia). ISSN 1335-6399 (Biologia. Section Cellular and Molecular Biology).


Full Paper

A comparative study of serological parameters in coxsackie virus B4 infected mice by intraperitoneal and oral route.


Shubhada Bopegamage*, Maria Stara & Anna Petrovicova

Institute of Preventive and Clinical Medicine, Limbova 14, SK-83301 Bratislava, Slovakia; fax: ++ 421 7 54773906, e-mail:

* corresponding author

Received: January 19, 2001 / Accepted: May 18, 2001



The etiological role of coxsackie B4 viruses as one of the triggering factors of IDDM have been indicated in experimental and epidemiological studies. Though the intraperitoneal (i.p.) route of infection is commonly used in the experimental murine model, little data are available on the natural oral route of infection. The study presents the comparison of the serum glucose levels and serological parameters such as titres of virus neutralising antibodies, alpha, beta and gamma interferon production, during the two modes of (infection i.p. and oral) at different time intervals up to day 56 post infection (p.i.). Differences in the antibody and the alpha/beta and gamma interferon levels and their temporal kinetics during the different modes of infection were observed.


Key words: coxsackievirus B4, intraperitoneal route of infection, oral route of infection, interferons.