Biologia, Bratislava, 55/Suppl. 8: 113-117, 2000.

ISSN 0006-3088 (Biologia). ISSN 1335-6399 (Biologia. Section Cellular and Molecular Biology).


Full Paper

Antimutagenic effect of copper (II) complexes with mephanamate and flufenamate.


Elena Szabova1*, Maria Mikulasova2, Jaroslav Cerny3 & Milan Melnik4

1 Institute of Preventive and Clinical Medicine, Limbova 14, SK-83301 Bratislava, Slovakia; tel.: ++ 421 7 59369241; e-mail:

2 Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak University of Technology, Slovakia

3 Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, SK-84206 Bratislava, Slovakia

4 Department of Inorganic Chemistry, Faculty of Chemical Technology, Slovak University of Technology, Radlinskeho 9, SK-81237 Bratislava, Slovakia

* corresponding author

Received: July 10, 2000 / Accepted: October 24, 2000



The copper (II) complex of 2-[(2,3-dimethylphenyl)-amino]benzoate (mephanamate)  and its ronicol adduct and copper (II) complex of N-(aaa-trifluoro-m-tolyl)anthranilate (flufenamate) and its ronicol adduct were tested for their potential antimutagenic effect. The compounds tested were found to have no mutagenic effect, however the obtained results suggested that they modified the mutagenic frequency in Salmonella typhimurium induced by some direct mutagens, and especially by promutagens 2-aminoanthracene and 2-aminofluorene in the presence of metabolic activation with S9. The potential antimutagenic activity will probably be associated with the copper properties to participate in a number of different biological processes and its interaction with DNA.


Key words: copper (II) mephanamate, copper (II) flufenamate, antimutagenic effect.