Biologia, Bratislava, 55/Suppl. 8: 23-26, 2000.
ISSN 0006-3088 (Biologia). ISSN 1335-6399 (Biologia. Section Cellular and Molecular Biology).
1st Childrenīs Hospital, School of Medicine, Comenius University, Limbova 1, SK-83340 Bratislava, Slovakia
* corresponding author
Received: July 10, 2000 / Accepted: October 24, 2000
The current approach to the problem of asphyxia of the newborn is presented. Despite the considerable progress in new diagnostic and therapeutic methods, asphyxia does still occur, and that not only in pre-term but also in full-term babies. The paper deals with suspected causes of asphyxia and mechanisms of its pathogenesis. Basic diagnostic possibilities and potential consequences of asphyxia are summarised. A broad range of complications may occur. Asphyxia affects the central nervous, cardiovascular, respiratory, gastrointestinal, haemopoetic and uropoetic systems, as well as the adrenal glands and the skin. Injury of cells of the central nervous system is considered the most severe affection involved. Early optimal treatment is mandatory. The need of new protective drugs with a narrow spectrum of action and minimal adverse effects is emphasised.
Key words: perinatal asphyxia, newborn.