Biologia, Bratislava 54/Suppl. 6: 47-49, 1999.

ISSN 0006-3088 (Biologia). ISSN 1335-6399 (Biologia. Section Cellular and Molecular Biology).

 

Review

Do the embryonic assumptions for the reconstruction of the myelocele exist?

 

Jozef Zlatos* & Pavel Nadvornik

Institute of Histology and Embryology, Faculty of Medicine, Comenius University, Sasinkova 4, SK-81108 Bratislava, Slovakia; tel.: ++421 7 5935 7284, fax: ++421 7 5935 7538, e-mail: histologia@fmed.uniba.sk

* corresponding author

Received: November 13, 1998 / Accepted: October 5, 1999

 

Abstract

The myelocele that usually affects the lumbar and sacral segments of the spinal cord occurs from the 4th week of the development of the embryo due to the failure of neural tube to close. While the dorsal horns of the spinal cord are absent, the motoneurons of the ventral horns develop and their axons grow to the periphery. The neural fibers of the spinal ganglia also take part on the peripheral nerves. The neural cells and fibers of the spinal ganglia arise from the neural crest independently on the neural tube, but their afferent connections to the spinal cord cannot be realized from the reason of myelocele. The result is a weak paralysis, a loss of sensibility and the trophic breakdowns. Therapeutically, it is possible to correct the spinal cord defect by a transplantation of embryonic neural tissue to replace the missing dorsal spinal horns.

 

Key words: myelocele, spinal cord, developmental defects, nervous tissue transplantation, neurotransplantation.