Biologia, Bratislava 54/Suppl. 6: 121-128, 1999.

ISSN 0006-3088 (Biologia). ISSN 1335-6399 (Biologia. Section Cellular and Molecular Biology).


Full paper

Histochemical localization of alkaline phosphatase (AP) and dipeptidyl peptidase (DPP) IV activities in the murine submandibular gland during pregnancy and lactation.


Blanka Pospisilova*, Olga Prochazkova, Dasa Slizova, Otakar Krs & Petr Bilek

Department of Anatomy, Charles University, Faculty of Medicine, Simkova 870, CZ-500 01 Hradec Kralove, Czech Republic; tel.:++420 49 5816230, fax: ++420 49 5511711, e-mail:

* corresponding author

Received: Januaryh 8, 1999 / Accepted: October 5, 1999



The histochemical localization of AP and DPP IV activities in the submandibular gland of pregnant and lactating female mice was studied and compared with activities of these enzymes in the submandibular gland of control adult males and virgin females. During gestation, a significant increase of AP and DPP IV activities was detected in the pregnant female glandular parenchyma. Between 15 to 21 days of gestation, the enzymic pattern of AP and DPP IV activities in submandibular gland of pregnant females was the same as in adult male gland. This finding suggests that in addition to androgens, progesterone also exerts masculinization of the murine submandibular gland.


Key words: alkaline phosphatase, dipeptidyl peptidase IV, submandibular gland, mouse, sexual dimorphism, pregnancy.