Biologia, Bratislava 54/Suppl. 6: 35-39, 1999.

ISSN 0006-3088 (Biologia). ISSN 1335-6399 (Biologia. Section Cellular and Molecular Biology).

 

Review

Molecular properties of the inositol (1,4,5) trisphosphate receptors from intracellular calcium stores.

 

Radovan Murin1, Jan Lehotsky1*, Peter Racay1, Jana Fedorova2 & Peter Kaplan1

1 Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University, Mala Hora 4, SK-03601 Martin, Slovakia; tel.: ++421 842 31565, fax: ++421 842 36770, e-mail: Lehotsky@jfmed.uniba.sk

2 Clinic of Heamatology, Jessenius Faculty of Medicine, Comenius University, Mala Hora 4, SK-03601 Martin, Slovakia

* corresponding author

Received: December 16, 1998 / Accepted: October 5, 1999

 

Abstract

The article briefly reviews recent published data on neuronal Ca2+ stores and their InsP3 receptors. The InsP3 receptor is a Ca2+ releasing channel that allows Ca2+ release in response to the binding of InsP3. Several genes, which share extensive structural homology, encode the InsP3 receptor. The InsP3 is modulated in a complex way by various cellular components. The regulation of InsP3 is important in several aspects of cellular calcium signalling.

 

Key words: calcium stores, inositol (1,4,5) trisphosphate receptor, regulation.